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Genetics of Obesity, Insulin Resistance, Subcutaneous Fat, and Fatty Liver: Relationships of Apolipoproteins B, E, and C3 and PPAR-γ Gene Polymorphisms and Other Candidate Genes
Dr. Misra and his team were first to show the negative association of apolipoprotein-B gene polymorphisms with generalized and regional obesity for Asian Indians in India. Recently, they reported a strong association of apolipoprotein-E4 allele with early-onset of coronary heart disease.
They investigated genotype-phenotype correlations of peroxisome-proliferator receptor-α and γ genes with obesity, diabetes mellitus and hyperlipidemia in Asian Indians.
Studies of polymorphisms of 13 genes as genetic determinants of insulin resistance and subcutaneous body fat are ongoing.
d. Similarly, Dr. Misra and his team are also investigating the genetic association of fatty liver with peroxisome-proliferator receptor-α and γ genes.
Collaborative Studies with Department of Cardiology, University of Maryland:
In collaboration with Dr. Mike Miller (University of Maryland, MD, USA), Dr. Misra has investigated polymorphisms of APOC3 promoter (C-482T,T-455C), APOE genotypes (2/3/4), PPAR alpha (intron 7: G/C), PPAR gamma (Pro12Ala), GNB3 (C825T and G814A), B3AR (Trp64Arg), FABP2 (Ala54Thr) and LPL (-93 T/G) in Asian Indians in India and Caucasians in USA. These data demonstrate that the prevalence of the metabolic syndrome was particularly elevated in homozygotes with the APOC3 promoter polymorphism variants (C-482T, T-455C) and raises the possibility that alterations in a single-gene may contribute to the metabolic syndrome.
Sub Categories links
Body Composition of Asian Indians and New definitions of Obesity and Syndrome X
Genetics of Obesity, Insulin Resistance, Subcutaneous Fat, and Fatty Liver
Contribution to National Health Policy and International Health Guidelines
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